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Non-Animal Platform for Nanoparticle-Based Delivery Across the Blood-Brain Barrier Interface with Vehicle Evolution

Non-Animal Platform for Nanoparticle-Based Delivery Across the Blood-Brain Barrier Interface with Vehicle Evolution

Time

1.1.2025–31.12.2028

Project coordinator

Åbo Akademi University

Other partners

  • Finnadvance Oy
  • AstraZeneca Ab
  • University of Gothenburg
  • Chalmers University of Technology
  • Microfluidics Innovation Center
  • Delft University of Technology
  • HansaBioMed Life Sciences Ou
  • Betthera s.r.o.
  • AMIRES s.r.o.
  • Eindhoven University of Technology
  • Funded by

  • European Commission (HORIZON-HLTH-2024- TOOL-05-06-two-stage)
  • Budget

    7 767 276 euros

    Åbo Akademi University’s part of the budget

    2 388 109 euros (31%)

    The blood-brain barrier (BBB) is a major obstacle in treating diseases of the central nervous system (CNS) such as Parkinson’s, Alzheimer’s, schizophrenia and brain cancer, affecting 180 million Europeans with less than 5% of current candidate drugs effectively reaching the brain. NAP4DIVE strives to revolutionize the traditionally expensive and inefficient drug development for these diseases by establishing advanced non-animal alternatives for testing and predicting nanoparticle (NP)-based drug delivery across the human BBB. This approach aligns with EU and global initiatives to reduce animal testing and advance human-based biomedical research models.

    Contact us

    Cecilia Sahlgren (Principal Investigator)

    Professor 

    Biochemistry and Cell Biology

    Faculty of Science and Engineering

    Jessica Rosenholm (Principal Investigator)

    Professor 

    Pharmacy

    Faculty of Science and Engineering

    Hongbo Zhang (Principal Investigator)

    Professor 

    Pharmacy

    Faculty of Science and Engineering

    Sebastien Lafond (Principal Investigator)

    Professor 

    Information Technology

    Faculty of Science and Engineering
    To the project page in the research portal of Åbo Akademi University