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Mikroskopbild från Inflammatory Signalling Lab:s forskning.

Inflammatory Signalling Lab

Mikroskopbild från Inflammatory Signalling Lab:s forskning.

Inflammatory Signalling Lab

Logo för Inflammatory Signalling Lab.




Omslag av the FEBS Journal.


Aalto AL, Luukkonen V, Meinander A (2023) Ubiquitin signalling in Drosophila innate immune responses. FEBS J. In press. doi: 10.1111/febs.17028.

Aalto AL, Saadabadi A, Lindholm F, Kietz C, Himmelroos E, Marimuthu P, Salo-Ahen OMH, Eklund P, Meinander (2023) Stilbenoid compounds inhibit NF-kappaB-mediated inflammatory responses in the Drosophila intestine Front. Immunol. 14:1253805. doi: 10.3389/fimmu.2023.1253805.

Virtanen L, Holm E, Halme M, West G, Lindholm F, Gullmets J, Irjala J, Heliö T, Padzik A, Meinander A, Eriksson JE, Taimen P (2023) Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress. J. Cell Sci. 136:jcs259788. doi: 10.1242/jcs.259788.

Kietz C, Meinander A (2023) Drosophila caspases as guardians of host-microbe interactions. Cell Death Differ. 30:227-236. doi: 10.1038/s41418-022-01038-4.

Mung KL, Meinander A, Koskinen P (2023)PIM kinases phosphorylate lactate dehydrogenase A at serine 161 and suppress its nuclear ubiquitination. FEBS J. 290:2489-2502. doi: 10.1111/febs.16653.

Aalto A, Martínez-Chacón G, Kietz C, Tsuganova N, Sundén M, Broemer M, Meinander A (2022) M1-ubiquitination facilitates NF-kappaB activation and survival during sterile inflammation. FEBS J. 289: 5180-5197. doi: 10.1111/febs.16425. Editor’s Choice article in FEBS J. Volume 289, Issue 17, 2022. Highlighted by Peltzer N: Linear ubiquitin as a common regulator of cellular stress (doi: 10.1111/febs.16427)

Şen Karaman D, Kietz C, Govardhanam P, Slita A, Manea A, Pamukçu A, Meinander A, Rosenholm J (2022) Core@shell structured ceria@mesoporous silica nanoantibiotics restrain bacterial growth in vitro and in vivo. Biomater. Adv. (Mater. Sci. Eng., C) 133:112607. doi: 10.1016/j.msec.2021.112607.

West G, Turunen M, Aalto A, Virtanen L, Li S-P, Heliö TM, Meinander A, Taimen P (2022) A heterozygous p.S143P mutation in LMNA associates with proteasome dysfunction and enhanced autophagy-mediated degradation of mutant lamins A and C. Front. Cell Dev. Biol. 10:932983. doi: 10.3389/fcell.2022.932983.

Kietz C, Mohan AK, Pollari V, Tuominen I-E, Ribeiro PS, Meier P, Meinander A (2021) Drice restrains Diap2-mediated inflammatory signalling and intestinal inflammation. Cell Death Differ. 29:28-39. doi: 10.1038/s41418-021-00832-w.

Qiao X, Liu Y, Llamazares Prada M, Mohan A, Gupta A, Jaiswal A, Sharma M, Haikala H, Talvinen K, Yetukuri L, Pylvänäinen JW, Klefström J, Kronqvist P, Meinander A, Aittokallio T, Hietakangas V, Eilers M, Westermarck J (2020) UBR5 is co-amplified with MYC in breast tumors and encodes a ubiquitin ligase that limits MYC-dependent apoptosis. Cancer Res. 80:1414-1427. doi: 10.1158/0008-5472.CAN-19-1647.

Aalto A, Mohan AK, Schwintzer L, Kupka S, Walczak H, Broemer M, Meinander A (2019) M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila. Cell Death Differ. 26: 860–876. doi: 10.1038/s41418-018-0164-x.

Kietz C, Pollari V, Meinander A (2018) Generating Germ-Free Drosophila to Study Gut-Microbe Interactions: Protocol to Rear Drosophila under Axenic Condition. Curr. Protoc. Toxicol. 77:e52. doi: 10.1002/cptx.52. T

Gullmets J, Torvaldson E, Lindqvist J, Imanishi SY, Taimen P, Meinander A*, Eriksson JE* (2017) Internal epithelia in Drosophila display rudimentary competence to form cytoplasmic networks of transgenic human vimentin. FASEB J. 12: 5332-5341. doi: 10.1096/fj.201700332R *equal contribution.

Sahlgren C, Meinander A, Zhang H, Cheng F, Preis M, Xu C, Salminen TA, Toivola D, Abankwa D, Rosling A, Karaman DŞ, Salo-Ahen OMH, Österbacka R, Eriksson JE, Willför S, Petre I, Peltonen J, Leino R, Johnson M, Rosenholm J, Sandler N (2017) Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems. Adv. Healthcare Mater. 6: 1700258. doi: 10.1002/adhm.201700258

Meinander A, Runchel C, Tenev T, Chen L, Kim C-H, Ribeiro PS, Broemer M, Leulier F, Zvelebil M, Silverman N and Meier P (2012) Ubiquitylation of the Initiator Caspase Dredd is Required for Innate Immune Signalling. EMBO J. 31: 2770-2783. doi: 10.1038/emboj.2012.121. Highlighted by Falschlehner C & Boutros M: Innate immunity: regulation of caspases by IAP-dependent ubiquitylation. doi: 10.1038/emboj.2012.148

Toivonen HT, Meinander A, Asaoka T, Westerlund M, Pettersson F, Mikhailov A, Eriksson JE, and Saxén H (2011) Modeling reveals that dynamic regulation of c-FLIP levels determines cell-to-cell distribution of CD95-mediated apoptosis. J. Biol. Chem. 286: 18375-18382. doi: 10.1074/jbc.M110.177097

Petre I, Mizera A, Hyder CL, Meinander A, Mikhailov A, Morimoto RI, Eriksson JE, Sistonen L, Morimoto RI, and Back R-J (2011) A simple mass action model for the eukaryotic heat shock response and its mathematical validation. Nat. Comput. 10: 595-612. 10.1007/s11047-010-9216-y

Blom T, Bergelin N, Meinander A, Löf C, Slotte JP, Eriksson JE, and Törnquist K (2010) An autocrine sphingosine-1-phosphate signaling loop enhances NF-κB-activation and survival. BMC Cell Biol. 11: 45. doi: 10.1186/1471-2121-11-45.

Rosenholm JM, Meinander A, Peuhu E, Niemi R, Eriksson JE, Sahlgren CM, and Lindén M (2009) Targeting of porous hybrid silica nanoparticles to cancer cells. ACS Nano. 3: 197-206. doi: 10.1021/nn800781r

Kaunisto A, Kochin V, Asaoka T, Mikhailov A, Poukkula M, Meinander A, and Eriksson JE (2009) PKC-mediated phosphorylation regulates c-FLIP ubiquitylation and stability. Cell Death Differ. 16: 1215-1226. doi: 10.1038/cdd.2009.35

Elphick LM, Hawat M, Toms NJ, Meinander A, Mikhailov A, Eriksson JE, and Kass GEN (2008) Opposing roles for caspase and calpain death proteases in L-glutamate-induced oxidative neurotoxicity. Toxicol. Appl. Pharmacol. 232: 258-267. doi: 10.1016/j.taap.2008.07.008

Meinander A, Söderström TS, Kaunisto A, Poukkula M, Sistonen L, and Eriksson JE (2007) Fever-like hyperthermia controls T-lymphocyte persistence by inducing degradation of c-FLIPshort. J. Immunol. 178: 3944-3953. doi: 10.4049/jimmunol.178.6.3944

Elphick LM, Meinander A, Mikhailov A, Richard M, Toms, NJ, Eriksson JE, and Kass GEN (2006) Live cell detection of caspase-3 activation by a Discosoma-red-fluorescent-protein-based fluorescence resonance energy transfer construct. Anal. Biochem. 349: 148-155. doi: 10.1016/j.ab.2005.11.031

Tran SEF, Meinander A, and Eriksson JE (2004) Instant decisions: transcription-independent control of death receptor-mediated apoptosis. Trends Biochem. Sci. 11: 601-606. doi: 10.1016/j.tibs.2004.09.009

Tran SEF, Meinander A, Holmström TH, Riviero-Muller A, Heiskanen KM, Linnau EK, Courtney MJ, Mosser DD, Sistonen L, and Eriksson JE (2003) Heat stress downregulates FLIP and sensitizes cells to Fas receptor-mediated apoptosis. Cell Death Differ. 10: 1137-1147. doi: 10.1038/sj.cdd.4401278.

Härmälä-Braskén AS, Mikhailov A, Söderström T, Meinander A, Holmström TH, Damuni Z, and Eriksson JE (2003) Type-2A protein phosphatase activity is required to maintain death receptor responsiveness. Oncogene 22: 7677-7686. doi: 10.1038/sj.onc.1207077

Holmberg CI, Hietakangas V, Mikhailov A, Rantanen JO, Kallio M, Meinander A, Hellman J, Morrice N, MacKintosh C, Morimoto RI, Eriksson JE, and Sistonen L (2001) Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J. 20: 3800-3810. doi: 10.1093/emboj/20.14.3800

Updated 29.2.2024