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Press release

Press release

An easy-to-use platform is a gateway to AI in microscopy

A new, freely available platform helps non-experts use artificial intelligence to analyse microscopy images. The platform has been developed at Åbo Akademi University in Finland and Instituto Gulbenkian de Ciência, Portugal, and will be of big help in research and diagnostics using modern day microscopes.

Software using artificial intelligence, AI, is revolutionizing how microscopy images are analysed. For instance, AI can be used to detect features in images (i.e., tumours in biopsy samples) or improve the quality of images by removing unwanted noise. However, non-experts continue to find AI technologies difficult to use.

In the article “Democratising deep learning for microscopy with ZeroCostDL4Mic”, published in Nature Communication on 15 April 2021, researchers describe a platform called ZeroCostDL4Mic, which makes these AI technologies accessible to everyone.

“The key novelty is that ZeroCostDL4Mic runs in the cloud for free and does not require users to have any coding experience or advanced computational skills. Effectively, it runs on any computer that has a web browser,” says Guillaume Jacquemet, Senior Researcher in Cell Biology at Åbo Akademi University.

Image of cancer cells in a yellow tone on a red background.

Image of cancer cells in different colours on a black background.
Example illustrating how AI via ZeroCostDL4Mic can be used to detect the nucleus of cancer cells from microscopy images. Upper picture: Original microscopy image. Lower picture: Image where each detected cancer cell has a different colour. Pictures: Guillaume Jacquemet.

Over the last 400 years, microscopes have allowed mankind to observe objects that are otherwise too small to be seen with the naked eye. Today, microscopy is a leading technology used worldwide to perform not only research but also diagnostics.

Modern microscopes are directly connected to digital cameras, leading to the acquisition of hundreds to thousands of images per sample. These images need to be processed on a computer to gain meaningful data, which is a huge undertaking.

To help with the number of images, Jacquemet and his colleagues have used AI to train a machine to do the work. In practice, ZeroCostDL4Mic is a collection of self-explanatory notebooks for Google Colab, featuring an easy-to-use graphical user interface.

“We believe that ZeroCostDL4Mic will acts as ‘a gateway drug’ for AI, luring users to explore these new technologies that will transform biomedical research and diagnostics in the decades to come,” says Jacquemet.

The development of the ZeroCostDL4Mic platform was coordinated by Guillaume Jacquemet’s (Åbo Akademi University, Turku, Finland) and Ricardo Henriques’ laboratories (Instituto Gulbenkian de Ciência, Oeiras, Portugal). It involved a large international consortium encompassing 12 laboratories, spread across nine countries and two continents.

ZeroCostDL4Mic is freely available online (https://github.com/HenriquesLab/ZeroCostDL4Mic), and a video highlighting examples is available here: https://www.youtube.com/watch?v=hh2I5xJH67k. The video illustrates how ZeroCostDL4Mic can detect and follow cancer cells in videos and improve the quality and resolution of various microscopy images.

Solutions for Health is one of the focal research areas at Åbo Akademi University.

Low-resolution picture with unsharp edges.

High-resolution picture with sharp edges.
Example illustrating how AI via ZeroCostDL4Mic can be used to improve the quality of microscopy images. The images are breast cancer cells stained to visualize their actin cytoskeleton and imaged using super-resolution microscopy. Upper picture: A noisy microscopy image. Lower picture: An improved image. Pictures: Guillaume Jacquemet.

The article ”Democratising deep learning for microscopy with ZeroCostDL4Mic” is published open access on https://doi.org/10.1038/s41467-021-22518-0.


More information:
Guillaume Jacquemet
Senior Researcher in Cell Biology at Åbo Akademi University
E-mail: guillaume.jacquemet@abo.fi
Tel. +358 503235606