The glycolipid transfer protein GLTP - A lipid
sorting orchestrator in health and disease
Glykolipidtransportproteinet GLTP - En lipidsorterare
i halsa och sjukdom
Glykolipidisiirtajaproteiini GLTP - lipidien
lajittelija terveydessa ja sairaudessa
Recent publications.
Rongzhen Deng, Ze Zheng, Shaofan Hu, Meng
Wang, Jing Feng, Peter Mattjus, Zhengwen Zhang and Yiguo
Zhang.
Loss of Nrf1 rather than Nrf2 leads to
inflammatory accumulation of lipids and reactive
oxygen species in human hepatoma cells, which is
alleviated by 2-bromopalmitate. BBA -
Molecular Cell Research, 2023.
PDF.
Henrik Nurmi, Anders P.E. Backman, Josefin Halin, Max
Lönnfors, Tomas Blom, Pia Roos-Mattjus and Peter
Mattjus.
Glycolipid transfer protein knockout
disrupts vesicle trafficking to the plasma membrane.
Journal of Biological Chemistry, 2023.
PDF.
Anders
Backman and Peter Mattjus.
Who moves the sphinx? An
overview of intracellular sphingolipid transport.
BBA - Molecular and Cell Biology of Lipids, 2021.
PDF.
Andrea
Dichlberger, Kecheng Zhou, Nils Bäck, Thomas Nyholm,
Anders Backman, Peter Mattjus, Elina Ikonen, Tomas Blom.
LAPTM4B controls the sphingolipid and ether lipid
signature of small extracellular vesicles. BBA -
Molecular and Cell Biology of Lipids, 2021.
PDF.
Lisa
Hahnefeld, Lisa Gruber, Nina Schomel, Caroline Fischer,
Peter Mattjus, Robert Gurke, Martina Beretta, Nerea
Ferreiros, Gerd Geisslinger and Marthe-Susanna Wegner.
Ether
lipid and sphingolipid expression patterns are
estrogen receptor-dependently altered in breast cancer
cells. International Journal of Biochemistry and
Cell Biology, 127 (2020) 105834.
PDF.
Anders
P. E. Backman, Josefin Halin, Matti A.
Kjellberg, and Peter Mattjus. Indirect
lipid transfer protein activity measurements
using quantification of glycosphingolipid
production.
Methods in Molecular Biology.
2019, in press. ISBN
978-1-4939-9136-5. PDF.
Anders
P. E. Backman, Josefin Halin, Henrik Nurmi, Anna
Möuts, Matti A. Kjellberg and Peter Mattjus. Glucosylceramide
acyl chain length is sensed by
the glycolipid transfer protein.
PLOS
ONE, 2018, 10.1371/journal.pone.0209230.
PDF.
Yuancai
Xiang, Josefin Halin, Zhuo Fan,
Shaofan Hu, Meng Wang, Lu Qiu,
Zhengwen Zhang, Peter Mattjus
and Yiguo Zhang. Topovectorial
mechanisms control
the juxtamembrane
proteolytic
processing of Nrf1
to remove its
N-terminal
polypeptides during
maturation of the
CNC-bZIP factor. Toxicology
and Applied Pharmacology, 2018.
doi.org/10.1016/j.taap.2018.09.039. PDF.
Yuping
Zhu, Meng Wang, Yuancai Xiang,
Lu Qiu, Shaofan Hu, Zhengwen
Zhang, Peter Mattjus, Xiamei Zhu
and Yiguo Zhang.
Nach
is a novel
subgroup at an
early evolutionary
stage of the
CNC-bZIP subfamily
transcription
factors from the
marine bacteria to
humans. International
Journal of Molecular Sciences, doi:10.3390/ijms19102927.
PDF.
Marthe-Susanna
Wegner, Nina Schömel, Lisa
Gruber, Stephanie Beatrice
Oertel, Matti Aleksi Kjellberg,
Peter Mattjus, Jennifer Kurz,
Sandra Trautmann, Bing Peng,
Robert Ahrends, Gerd Geisslinger
and Sabine Grösch. UDP-glucose
ceramide
glucosyltransferase
activates AKT,
promoted
proliferation,
and
doxorubicin
resistance in
breast cancer
cells. Cellular
and Molecular Life Sciences,
2018 Mar 17.
doi:10.1007/s00018-018-2799-7.
PDF.
Nicola
De Franceschi,
Mitro
Miihkinen,
Hellyeh
Hamidi, Jonna
Alanko, Anja
Mai, Laura
Picas, Daniel
Lévy, Peter
Mattjus,
Benjamin T
Goult, Bruno
Goud and
Johanna
Ivaska.
ProLIF:
a quantitative
assay for
investigating
integrin
cytoplasmic
protein
interactions
and
synergistic
membrane
effects on
proteoliposomes.
J
Cell Sci.
2018 Aug
20;132(4). pii:
jcs214270. doi:
10.1242/jcs.214270.
PDF.
Marthe-Susanna
Wegner, Lisa Gruber, Peter
Mattjus, Gerd Geisslinger,
Sabine Grösch. The
UDP-glucose ceramide
glycosyltransferase (UGCG) and
the link to multidrug resistance
protein 1 (MDR1). Marthe-Susanna
Wegner, Lisa Gruber, Peter
Mattjus, Gerd Geisslinger and
Sabine Grösch. BMC
Cancer (2018) 18:153,
https://doi.org/10.1186/s12885-018-4084-4.
PDF.
Matti
A. Kjellberg, Anders P. E.
Backman, Anna Möuts, and Peter
Mattjus. Purification
and transfer assays of
sphingolipid recognising
proteins. Methods in
Molecular Biology. 2017, in
press. ISBN 978-1-4939-6995-1. PDF.
Peter
Mattjus. Specificity
of the mammalian glycolipid transfer
proteins. Chemistry
and Physics of Lipids 94 (2016),
72-7.
doi:10.1016/j.chemphyslip.2015.07.018 PDF.
Invited review, Robert
Bittman Memorial Issue.
Matti
A. Kjellberg, Max Lönnfors, J. Peter
Slotte and Peter Mattjus. Metabolic
conversion of ceramides in HeLa
cells - A cholesteryl phosphocholine
delivery approach.
PLoS ONE 2015 Nov
24;10(11):e0143385.
doi:10.1371/journal.pone.0143385. PDF.
Matti
A. Kjellberg, Anders P. E. Backman,
Henna Ohvo-Rekilä and Peter Mattjus. Alternation
in the Glycolipid Transfer Protein
Expression Causes Changes in the
Cellular Lipidome. PLoS
ONE 9(5): e97263. PDF.
Jessica
Tuuf and Peter Mattjus.
Membranes and mammalian glycolipid
transferring proteins. Chem
Phys Lipids. 178 (2014), 27–37.
PDF.
Link
to complete list of PDFs.
Funding
Jane & Aatos Erkko Foundation,
Magnus Ehrnrooth Foundation,
Medicinska Understodsforeningen Liv
och Halsa, Svenska Kulturfonden.